FMF ( Familial Mediterranean Fever)

Familial Mediterranean Fever (FMF) is characterized by recurrent short episodes of inflammation and serositis including fever, peritonitis, synovitis, pleuritis and rarely pericarditis and meninigitis. The symptoms vary among patients, sometimes even among membersof the same family. Amyloidosis, which can lead to renal failure, is the most sever complication.

Diagnosis :

Blood tests reveal a high erythrocyte sedimentation rate, leukocytosis and a high fibrinogen level.

Molecular genetic of MEFV gene confirms the diagnosis.

Molecular genetic testing is also used for carrier detection.


Colchicine prevents both the inflammatory attacks and the deposition of amyloid.

MEFV is the only gene currently known to be associated with Familial Mediterranean Fever and is routinely done in Metra Laboratories.